These formats carry most of the volume in pharmaceutical and medical-device distribution. 845 communicates the contract prices a wholesaler may sell at; 844 is the wholesaler’s chargeback claim; 867 reports what was actually sold and to whom.
The operational risk is silent partial loading. A rejected or incompletely processed file creates a gap in the sell-through basis that feeds both chargeback validation and administrative-fee calculation, and because nothing errors visibly, the gap is usually found during an annual reconciliation.
Schedule monitoring — alerting on a period that did not arrive, rather than only on a file that failed — is the control.